EC - Oxaloacetate decarboxylase

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IntEnz Enzyme Nomenclature


Accepted name:
oxaloacetate decarboxylase
Other names:
oxalacetic acid decarboxylase
oxalate β-decarboxylase
oxaloacetate β-decarboxylase
oxaloacetate carboxy-lyase
Systematic name:
oxaloacetate carboxy-lyase (pyruvate-forming)



Requires a divalent metal cation. The enzymes from the fish Gadus morhua (Atlantic cod) and the bacterium Micrococcus luteus prefer Mn2+, while those from the bacteria Pseudomonas putida and Pseudomonas aeruginosa prefer Mg2+. Unlike EC [oxaloacetate decarboxylase (Na+ extruding)], there is no evidence of the enzyme's involvement in Na+ transport.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00167 , PROSITE:PDOC50991
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008948
CAS Registry Number: 9024-98-0
UniProtKB/Swiss-Prot: (138) [show] [UniProt]


  1. Schmitt, A., Bottke, I., Siebert, G.
    [Properties of oxaloacetate decarboxylase from codfish muscles]
    Hoppe-Seyler's Z. Physiol. Chem. 347 : 18-34 (1966). [PMID: 5972993]
  2. Herbert, D.
    Oxalacetic carboxylase of Micrococcus lysodeikticus.
    Methods Enzymol. 1 : 753-757 (1955).
  3. Horton, A.A. and Kornberg, H.L.
    Oxaloacetate 4-carboxy-lyase from Pseudomonas ovalis chester.
    Biochim. Biophys. Acta 89 : 381-383 (1964). [PMID: 14205502]
  4. Sender, P. D., Martin, M. G., Peiru, S., Magni, C.
    Characterization of an oxaloacetate decarboxylase that belongs to the malic enzyme family.
    FEBS Lett. 570 : 217-222 (2004). [PMID: 15251467]
  5. Narayanan, B. C., Niu, W., Han, Y., Zou, J., Mariano, P. S., Dunaway-Mariano, D., Herzberg, O.
    Structure and function of PA4872 from Pseudomonas aeruginosa, a novel class of oxaloacetate decarboxylase from the PEP mutase/isocitrate lyase superfamily.
    Biochemistry 47 : 167-182 (2008). [PMID: 18081320]

[EC created 1961 as EC, modified 1986, modified 2000, part transferred 2018 to EC]