EC - 2-hydroxymuconate-6-semialdehyde hydrolase

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IntEnz Enzyme Nomenclature


Accepted name:
2-hydroxymuconate-6-semialdehyde hydrolase
Other names:
2-hydroxy-6-oxohepta-2,4-dienoate hydrolase
2-hydroxymuconic semialdehyde hydrolase
HOD hydrolase
xylF (gene name)
2-hydroxymuconate-semialdehyde formylhydrolase
2-hydroxymuconate-semialdehyde hydrolase
Systematic name:
2-hydroxymuconate-6-semialdehyde formylhydrolase



The enzyme is involved in the degradation of catechols.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018775


  1. Sala-Trepat, J.M. and Evans, W.C.
    The meta cleavage of catechol by Azotobacter species. 4-Oxalocrotonate pathway.
    Eur. J. Biochem. 20 : 400-413 (1971). [PMID: 4325686]
  2. Harayama, S., Rekik, M., Wasserfallen, A. and Bairoch, A.
    Evolutionary relationships between catabolic pathways for aromatics: conservation of gene order and nucleotide sequences of catechol oxidation genes of pWW0 and NAH7 plasmids.
    Mol. Gen. Genet. 210 : 241-247 (1987). [PMID: 3481421]
  3. Diaz, E., Timmis, K. N.
    Identification of functional residues in a 2-hydroxymuconic semialdehyde hydrolase. A new member of the alpha/beta hydrolase-fold family of enzymes which cleaves carbon-carbon bonds.
    J. Biol. Chem. 270 : 6403-6411 (1995). [PMID: 7890778]

[EC created 1990, modified 2013]