EC 3.7.1.3 - Kynureninase

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IntEnz Enzyme Nomenclature
EC 3.7.1.3

Names

Accepted name:
kynureninase
Systematic name:
L-kynurenine hydrolase

Reactions

Cofactor

Comments:

A pyridoxal-phosphate protein. Also acts on 3'-hydroxykynurenine and some other (3-arylcarbonyl)-alanines.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030429
CAS Registry Number: 9024-78-6
UniProtKB/Swiss-Prot: (83) [show] [UniProt]

References

  1. Jakoby, W.B. and Bonner, D.M.
    Kynureninase from Neurospora: purification and properties.
    J. Biol. Chem. 205: 699-707 (1953). [PMID: 13129248]
  2. Jakoby, W.B. and Bonner, D.M.
    Kynureninase from Neurospora: interactions of enzyme with substrates, coenzyme and amines.
    J. Biol. Chem. 205: 709-715 (1953). [PMID: 13129249]
  3. Knox, W.E.
    The relation of liver kynureninase to tryptophan metabolism in pyridoxine deficiency.
    Biochem. J. 53: 379-385 (1953). [PMID: 13032082]
  4. Wiss, O. and Weber, F.
    Die Reindarstellung der Kynureninase.
    Hoppe-Seyler's Z. Physiol. Chem. 304: 232-240 (1956).
  5. Lima, S., Khristoforov, R., Momany, C., Phillips, R. S.
    Crystal structure of Homo sapiens kynureninase.
    Biochemistry 46: 2735-2744 (2007). [PMID: 17300176]

[EC 3.7.1.3 created 1965]