EC 3.7.1.19 - 2,6-dihydroxypseudooxynicotine hydrolase

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IntEnz Enzyme Nomenclature
EC 3.7.1.19

Names

Accepted name:
2,6-dihydroxypseudooxynicotine hydrolase
Systematic name:
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase

Reaction

Comments:

The enzyme, characterized from the soil bacterium Arthrobacter nicotinovorans, participates in nicotine degradation.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Gherna, R. L., Richardson, S. H., Rittenberg, S. C.
    The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
    J. Biol. Chem. 240: 3669-3674 (1965). [PMID: 5835946]
  2. Sachelaru, P., Schiltz, E., Igloi, G. L., Brandsch, R.
    An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
    J. Bacteriol. 187: 8516-8519 (2005). [PMID: 16321959]

[EC 3.7.1.19 created 2012]