EC - 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
2-hydroxy-6-oxonona-2,4-dienedioate hydrolase
Other name:
mhpC (gene name)
Systematic name:
(2Z,4E)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase



This enzyme catalyses a step in a pathway of phenylpropanoid compounds degradation. The first step of the enzyme mechanism involves a reversible keto-enol tautomerization [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052823 , GO:0018771
UniProtKB/Swiss-Prot: (22) [show] [UniProt]


  1. Burlingame, R., Chapman, P. J.
    Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli.
    J. Bacteriol. 155 : 113-121 (1983). [PMID: 6345502]
  2. Burlingame, R. P., Wyman, L., Chapman, P. J.
    Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation.
    J. Bacteriol. 168 : 55-64 (1986). [PMID: 3531186]
  3. Lam, W. W. Y and Bugg, T. D. H.
    Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic clevage.
    J. Chem. Soc., Chem. Commun. 10 : 1163-1164 (1994).
  4. Lam, W. W., Bugg, T. D.
    Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase.
    Biochemistry 36 : 12242-12251 (1997). [PMID: 9315862]
  5. Ferrandez, A., Garcia, J. L., Diaz, E.
    Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
    J. Bacteriol. 179 : 2573-2581 (1997). [PMID: 9098055]
  6. Diaz, E., Ferrandez, A., Garcia, J. L.
    Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
    J. Bacteriol. 180 : 2915-2923 (1998). [PMID: 9603882]

[EC created 2011, modified 2012]