EC 3.6.5.6 - Tubulin GTPase

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IntEnz Enzyme Nomenclature
EC 3.6.5.6

Names

Accepted name:
tubulin GTPase
Systematic name:
GTP phosphohydrolase (microtubule-releasing)

Reaction

Comments:

An intrinsic activity of α-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00199
Structural data: CSA , EC2PDB

References

  1. Yu, X.C. and Margolin, W.
    Ca2+-mediated GTP-dependent dynamic assembly of bacetrial cell division protein FtsZ into asters and polymer networks in vitro.
    EMBO J. 16 : 5455-5463 (1997). [PMID: 9312004]
  2. Tian, G., Bhamidipati, A., Cowan, N.J . and Lewis, S.A.
    Tubulin folding cofactors as GTPase-activating proteins. GTP hydrolysis and the assembly of the α/β-tubulin heterodimer.
    J. Biol. Chem. 274 : 24054-24058 (1999). [PMID: 10446175]
  3. Roychowdhury, S., Panda, D., Wilson, L. and Rasenick, M.M.
    G protein α subunits activate tubulin GTPase and modulate microtubule polymerization dynamics.
    J. Biol. Chem. 274 : 13485-13490 (1999). [PMID: 10224115]

[EC 3.6.5.6 created 2000 as EC 3.6.1.51, transferred 2003 to EC 3.6.5.6]