EC 3 - Hydrolases
EC 3.6 - Acting on acid anhydrides
EC 3.6.5 - Acting on GTP; involved in cellular and subcellular movement
EC 3.6.5.5 - Dynamin GTPase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.6.5.5
Names
Accepted name:
dynamin GTPase
Systematic name:
GTP phosphohydrolase (vesicle-releasing)
Reaction
- GTP + H2O = GDP + phosphate
Comments:
An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane vesicles.
Links to other databases
Protein domains and families:
PROSITE:PDOC00362
References
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Dynamin GTPase, a force-generating molecular switch.Bioessays 18 : 885-893 (1996). [PMID: 8939066]
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Dynamin, endocytosis and intracellular signalling.Mol. Membr. Biol. 13 : 189-215 (1996). [PMID: 9116759]
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Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium.J. Cell Biol. 141 : 101-114 (1998). [PMID: 9531551]
[EC 3.6.5.5 created 2000 as EC 3.6.1.50, transferred 2003 to EC 3.6.5.5]