IntEnz

EC 3.6.5.5 - Dynamin GTPase

IntEnz Enzyme Nomenclature
EC 3.6.5.5

Names

Reaction

• 19669 [IUBMB]
  GTP

  GTP

  Name origin: UniProt - CHECKED (C)

  CHEBI:37565

  Formula: C10H12N5O14P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  GDP

  GDP

  Name origin: UniProt - CHECKED (C)

  CHEBI:58189

  Formula: C10H12N5O11P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  phosphate

  phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:43474

  Formula: HO4P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Comments:

An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane vesicles.

Links to other databases

References

1. Warnock, D.E. and Schmid, S.L.
   Dynamin GTPase, a force-generating molecular switch.
   Bioessays 18 : 885-893 (1996). [PMID: 8939066]
2. McClure, S.J. and Robinson, P.J.
   Dynamin, endocytosis and intracellular signalling.
   Mol. Membr. Biol. 13 : 189-215 (1996). [PMID: 9116759]
3. Oh, P., McIntosh, D.P. and Schnitzer, J.E.
   Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium.
   J. Cell Biol. 141 : 101-114 (1998). [PMID: 9531551]

[EC 3.6.5.5 created 2000 as EC 3.6.1.50, transferred 2003 to EC 3.6.5.5]