EC 3 - Hydrolases
EC 3.6 - Acting on acid anhydrides
EC 3.6.5 - Acting on GTP; involved in cellular and subcellular movement
EC 3.6.5.4 - Signal-recognition-particle GTPase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.6.5.4
Names
Accepted name:
signal-recognition-particle GTPase
Systematic name:
GTP phosphohydrolase (protein-synthesis-assisting)
Reaction
- GTP + H2O = GDP + phosphate
Comments:
Activity is associated with the signal-recognition particle (a protein- and RNA-containing structure involved in endoplasmic-reticulum-associated protein synthesis).
Links to other databases
Protein domains and families:
PROSITE:PDOC00272
References
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The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide.Cell 57 : 599-610 (1989). [PMID: 2541918]
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Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor.Science 252 : 1171-1173 (1991). [PMID: 1851576]
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GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation.Nature 366 : 351-354 (1993). [PMID: 8247130]
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Structure of the conserved GTPase domain of the signal recognition particle.Nature 385 : 361-364 (1997). [PMID: 9002524]
[EC 3.6.5.4 created 2000 as EC 3.6.1.49, transferred 2003 to EC 3.6.5.4]