EC - Signal-recognition-particle GTPase

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IntEnz Enzyme Nomenclature


Accepted name:
signal-recognition-particle GTPase
Systematic name:
GTP phosphohydrolase (protein-synthesis-assisting)



Activity is associated with the signal-recognition particle (a protein- and RNA-containing structure involved in endoplasmic-reticulum-associated protein synthesis).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00272
Structural data: CSA , EC2PDB


  1. Connolly, T. and Gilmore, R.
    The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide.
    Cell 57 : 599-610 (1989). [PMID: 2541918]
  2. Connolly, T., Rapiejko, P.J. and Gilmore, R.
    Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor.
    Science 252 : 1171-1173 (1991). [PMID: 1851576]
  3. Miller, J.D., Wilhelm, H., Gierasch, L., Gilmore, R. and Walter, P.
    GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation.
    Nature 366 : 351-354 (1993). [PMID: 8247130]
  4. Freymann, D.M., Keenan, R.J., Stroud, R.M. and Walter, P.
    Structure of the conserved GTPase domain of the signal recognition particle.
    Nature 385 : 361-364 (1997). [PMID: 9002524]

[EC created 2000 as EC, transferred 2003 to EC]