EC - Small monomeric GTPase

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IntEnz Enzyme Nomenclature


Accepted name:
small monomeric GTPase
Systematic name:
GTP phosphohydrolase (cell-regulating)



A family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the α-subunit of heterotrimeric G-protein GTPase (EC They are involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00859
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003925
UniProtKB/Swiss-Prot: (315) [show] [UniProt]


  1. Bourne, H.R., Sanders, D.A. and McCormick, F.
    The GTPase superfamily: conserved structure and molecular mechanisms.
    Nature 349 : 117-127 (1991). [PMID: 1898771]
  2. Hall, A.
    Small GTP-binding proteins and the regulation of actin cytoskeleton.
    Annu. Rev. Cell Biol. 10 : 31-54 (1994). [PMID: 7888179]
  3. Geyer, M. and Wittinghofer, A.
    GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins.
    Curr. Opin. Struct. Biol. 7 : 786-792 (1997). [PMID: 9434896]
  4. Vitale, N., Moss, J. and Vaughan, M.
    Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1).
    J. Biol. Chem. 273 : 2553-2560 (1998). [PMID: 9446556]

[EC created 2000 as EC, transferred 2003 to EC]