EC - Peroxisome-assembly ATPase

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IntEnz Enzyme Nomenclature


Accepted name:
peroxisome-assembly ATPase
Other name:
peroxisome assembly factor-2
Systematic name:
ATP phosphohydrolase (peroxisome-assembling)



An extremely diversified group of enzymes that use the energy of ATP hydrolysis to import and assemble peroxisome components into the organelle. Their molecular masses range from 25 to 600 kDa.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Lee, Y.J. and Wickner, R.B.
    AFG1, a new member of the SEC18-NSF, PAS1, CDC48-VCP, TBP family of ATPases.
    Yeast 8 : 787-790 (1992). [PMID: 1441755]
  2. Tsukamoto,T., Miura, S., Nakai, T., Yokota, S., Shimozawa, N., Suzuki, Y., Orii, T., Fujiki, Y., Sakai, F., Bogaki, A., Yasumo, H. and Osumi, T.
    Peroxisome assembly factor-2, a putative ATPase cloned by functional complementation on a peroxisome-deficient mammalian cell mutant.
    Nat. Genet. 11 : 395-401 (1995). [PMID: 7493019]
  3. Yahraus, T., Braverman, N., Dodt, G., Kalish, J.E., Morrell, J.C., Moser, H.W., Valle, D. and Gould, S.J.
    The peroxisome biogenesis disorder group 4 gene, PXAAA1, encodes a cytoplasmic ATPase required for stability of the PTS1 receptor.
    EMBO J. 15 : 2914-2923 (1996). [PMID: 8670792]

[EC created 2000]