EC 3 - Hydrolases
EC 3.6 - Acting on acid anhydrides
EC 3.6.4 - Acting on ATP; involved in cellular and subcellular movement
EC 3.6.4.6 - Vesicle-fusing ATPase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.6.4.6
Names
Accepted name:
vesicle-fusing ATPase
Systematic name:
ATP phosphohydrolase (vesicle-fusing)
Reaction
- ATP + H2O = ADP + phosphate
Comments:
A large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger's syndrome.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ERGO
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC00572
References
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A 200-amino acid ATPase module in search of a basic function.BioEssays 17 : 639-650 (1995). [PMID: 7646486]
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Temperature-sensitive mutation in PEX1 moderates the phenotypes of peroxisome deficiency disorders.Hum. Mol. Genet. 7 : 2089-2094 (1998). [PMID: 9817926]
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The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function.EMBO J. 17 : 2982-2983 (1998). [PMID: 9606181]
[EC 3.6.4.6 created 2000]