EC - Vesicle-fusing ATPase

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IntEnz Enzyme Nomenclature


Accepted name:
vesicle-fusing ATPase
Systematic name:
ATP phosphohydrolase (vesicle-fusing)



A large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger's syndrome.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00572
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (38) [show] [UniProt]


  1. Confalonieri, F. and Duguet, M.
    A 200-amino acid ATPase module in search of a basic function.
    BioEssays 17 : 639-650 (1995). [PMID: 7646486]
  2. Imamura, A., Tamura, S., Shimoyawa, N., Suzuki, Y., Zhang, Z., Tsukamoto, T., Orii, T., Kondo, N., Osumi, T. and Fujiki, Y.
    Temperature-sensitive mutation in PEX1 moderates the phenotypes of peroxisome deficiency disorders.
    Hum. Mol. Genet. 7 : 2089-2094 (1998). [PMID: 9817926]
  3. Babst, W., Wendland, B., Estepa, E.J. and Emr, S.D.
    The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function.
    EMBO J. 17 : 2982-2983 (1998). [PMID: 9606181]

[EC created 2000]