IntEnz

EC 3.6.4.6 - Vesicle-fusing ATPase

IntEnz Enzyme Nomenclature
EC 3.6.4.6

Names

Reaction

• 13065 [IUBMB]
  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  phosphate

  phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:43474

  Formula: HO4P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Comments:

A large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger's syndrome.

Links to other databases

References

1. Confalonieri, F. and Duguet, M.
   A 200-amino acid ATPase module in search of a basic function.
   BioEssays 17 : 639-650 (1995). [PMID: 7646486]
2. Imamura, A., Tamura, S., Shimoyawa, N., Suzuki, Y., Zhang, Z., Tsukamoto, T., Orii, T., Kondo, N., Osumi, T. and Fujiki, Y.
   Temperature-sensitive mutation in PEX1 moderates the phenotypes of peroxisome deficiency disorders.
   Hum. Mol. Genet. 7 : 2089-2094 (1998). [PMID: 9817926]
3. Babst, W., Wendland, B., Estepa, E.J. and Emr, S.D.
   The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function.
   EMBO J. 17 : 2982-2983 (1998). [PMID: 9606181]

[EC 3.6.4.6 created 2000]