EC - Myosin ATPase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
myosin ATPase
Other name:
Systematic name:
ATP phosphohydrolase (actin-translocating)



Proteins of the contractile apparatus of muscle and nonmuscle cells; myosin molecule consists of two heavy chains (about 200 kDa) and two pairs of light chains (15-27 kDa). The head region of the heavy chain contains actin- and ATP-binding sites. ATP hydrolysis provides energy for actomyosin contraction.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Rayment, I.
    The structural basis of myosin ATPase activity.
    J. Biol. Chem. 271: 15850-15853 (1996). [PMID: 8663496]
  2. Hasson, T. and Mooseker, M.S.
    Vertebrate unconventional myosins.
    J. Biol. Chem. 271: 16431-16434 (1996). [PMID: 8690736]
  3. Murphy, C.T. and Spudich, J.A.
    The sequence of the myosin 50-20K loop affects myosin's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity.
    Biochemistry 38: 3785-3792 (1999). [PMID: 10090768]

[EC created 1984 as EC, transferred 2000 to EC]