EC - Ca2+-transporting ATPase

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IntEnz Enzyme Nomenclature


Accepted name:
Ca2+-transporting ATPase
Other names:
Ca2+-pumping ATPase
calcium pump
plasma membrane Ca-ATPase
sarco(endo)plasmic reticulum Ca2+-ATPase
sarcoplasmic reticulum ATPase
calcium-translocating P-type ATPase
ca2+-transporting ATPase
Systematic name:
ATP phosphohydrolase (Ca2+-transporting)




A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme family comprises three types of Ca2+-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum and in yeast. The first and third transport one ion per ATP hydrolysed, whereas the second transports two ions.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00139
Structural data: CSA , EC2PDB
Gene Ontology: GO:0005388
UniProtKB/Swiss-Prot: (92) [show] [UniProt]


  1. Schatzmann, H.J. and Vicenzi, F.F.
    Calcium movements across the membrane of human red cells.
    J. Physiol. 201: 369-395 (1969). [PMID: 4238381]
  2. Inesi, G., Watanabe, T., Coan, C. and Murphy, A.
    The mechanism of sarcoplasmic reticulum ATPase.
    Ann. NY Acad. Sci. 402: 515-532 (1982). [PMID: 6301340]
  3. Carafoli, E.
    The Ca2+ pump of the plasma membrane.
    J. Biol. Chem. 267: 2115-2118 (1992). [PMID: 1310307]
  4. MacLennan, D.H., Rice, W.J. and Green, N.M.
    The mechanism of Ca2+ transport by sarco(endo)plasmic reticulum Ca2+-ATPases.
    J. Biol. Chem. 272: 28815-28818 (1997). [PMID: 9360942]

[EC created 1984 as EC, transferred 2000 to EC, modified 2001, modified 2011]