EC - Cu+ exporting ATPase

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IntEnz Enzyme Nomenclature


Accepted name:
Cu+ exporting ATPase
Other names:
Systematic name:
ATP phosphohydrolase (Cu+-exporting)



A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme transports Cu+ or Ag+, and cannot tranport the divalent ions, contrary to EC, Cu2+-exporting ATPase, which mainly transports the divalent copper ion.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (53) [show] [UniProt]


  1. Fan, B., Rosen, B. P.
    Biochemical characterization of CopA, the Escherichia coli Cu(I)-translocating P-type ATPase.
    J. Biol. Chem. 277: 46987-46992 (2002). [PMID: 12351646]
  2. Banci, L., Bertini, I., Ciofi-Baffoni, S., D'Onofrio, M., Gonnelli, L., Marhuenda-Egea, F. C., Ruiz-Duenas, F. J.
    Solution structure of the N-terminal domain of a potential copper-translocating P-type ATPase from Bacillus subtilis in the apo and Cu(I) loaded states.
    J. Mol. Biol. 317: 415-429 (2002). [PMID: 11922674]
  3. Mandal, A. K., Arguello, J. M.
    Functional roles of metal binding domains of the Archaeoglobus fulgidus Cu+-ATPase CopA.
    Biochemistry 42: 11040-11047 (2003). [PMID: 12974640]
  4. Gonzalez-Guerrero, M., Arguello, J. M.
    Mechanism of Cu+-transporting ATPases: soluble Cu+ chaperones directly transfer Cu+ to transmembrane transport sites.
    Proc. Natl. Acad. Sci. USA 105: 5992-5997 (2008). [PMID: 18417453]
  5. Lewis, D., Pilankatta, R., Inesi, G., Bartolommei, G., Moncelli, M. R., Tadini-Buoninsegni, F.
    Distinctive features of catalytic and transport mechanisms in mammalian sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) and Cu+ (ATP7A/B) ATPases.
    J. Biol. Chem. 287: 32717-32727 (2012). [PMID: 22854969]
  6. Tadini-Buoninsegni, F., Bartolommei, G., Moncelli, M. R., Pilankatta, R., Lewis, D., Inesi, G.
    ATP dependent charge movement in ATP7B Cu+-ATPase is demonstrated by pre-steady state electrical measurements.
    FEBS Lett. 584: 4619-4622 (2010). [PMID: 20965182]
  7. Mattle, D., Sitsel, O., Autzen, H. E., Meloni, G., Gourdon, P., Nissen, P.
    On Allosteric Modulation of P-Type Cu(+)-ATPases.
    J. Mol. Biol. 425: 2299-2308 (2013). [PMID: 23500486]

[EC created 2013]