EC 184.108.40.206 - 8-oxo-(d)GTP phosphatase
IntEnz Enzyme Nomenclature
- (1) 8-oxo-GTP + H2O = 8-oxo-GDP + phosphate
- (2) 8-oxo-dGTP + H2O = 8-oxo-dGDP + phosphate
The enzyme, characterized from the bacterium Mycobacterium tuberculosis, catalyses the hydrolysis of both 8-oxo-GTP and 8-oxo-dGTP, thereby preventing transcriptional and translational errors caused by oxidative damage. The enzyme is highly specific. Unlike EC 220.127.116.11, 8-oxo-dGTP diphosphatase, it removes only a single phosphate group. The nucleoside diphosphate products are hydrolysed further by EC 18.104.22.168, 8-oxo-dGDP phosphatase.
Links to other databases
Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance.J. Biol. Chem. 288 : 11252-11262 (2013). [PMID: 23463507]
[EC 22.214.171.124 created 2019]