EC 3.6.1.69 - 8-oxo-(d)GTP phosphatase

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IntEnz Enzyme Nomenclature
EC 3.6.1.69

Names

Accepted name:
8-oxo-(d)GTP phosphatase
Systematic name:
8-oxo-dGTP diphosphohydrolase

Reactions

Comments:

The enzyme, characterized from the bacterium Mycobacterium tuberculosis, catalyses the hydrolysis of both 8-oxo-GTP and 8-oxo-dGTP, thereby preventing transcriptional and translational errors caused by oxidative damage. The enzyme is highly specific. Unlike EC 3.6.1.55, 8-oxo-dGTP diphosphatase, it removes only a single phosphate group. The nucleoside diphosphate products are hydrolysed further by EC 3.6.1.58, 8-oxo-dGDP phosphatase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008413
UniProtKB/Swiss-Prot:

References

  1. Patil, A. G., Sang, P. B., Govindan, A., Varshney, U.
    Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance.
    J. Biol. Chem. 288 : 11252-11262 (2013). [PMID: 23463507]

[EC 3.6.1.69 created 2019]