EC - XTP/dITP diphosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
XTP/dITP diphosphatase
Other names:
hypoxanthine/xanthine dNTP pyrophosphatase
rdgB (gene name)
Systematic name:
XTP/dITP diphosphohydrolase (diphosphate-forming)




The enzymes from the bacterium Escherichia coli and the archaea Methanococcus jannaschii and Archaeoglobus fulgidus are highly specific for XTP, dITP and ITP. The activity is dependent on divalent cations, Mg2+ is preferred.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0036222 , GO:0035870
UniProtKB/Swiss-Prot: (256) [show] [UniProt]


  1. Chung, J. H., Back, J. H., Park, Y. I., Han, Y. S.
    Biochemical characterization of a novel hypoxanthine/xanthine dNTP pyrophosphatase from Methanococcus jannaschii.
    Nucleic Acids Res. 29 : 3099-3107 (2001). [PMID: 11452035]
  2. Chung, J. H., Park, H. Y., Lee, J. H., Jang, Y.
    Identification of the dITP- and XTP-hydrolyzing protein from Escherichia coli.
    J. Biochem. Mol. Biol. 35 : 403-408 (2002). [PMID: 12297000]
  3. Hwang, K. Y., Chung, J. H., Kim, S. H., Han, Y. S., Cho, Y.
    Structure-based identification of a novel NTPase from Methanococcus jannaschii.
    Nat. Struct. Biol. 6 : 691-696 (1999). [PMID: 10404228]
  4. Savchenko, A., Proudfoot, M., Skarina, T., Singer, A., Litvinova, O., Sanishvili, R., Brown, G., Chirgadze, N., Yakunin, A. F.
    Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli.
    J. Mol. Biol. 374 : 1091-1103 (2007). [PMID: 17976651]

[EC created 2013]