EC - (d)CTP diphosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
(d)CTP diphosphatase
Other names:
(d)CTP pyrophosphohydrolase
(d)CTP diphosphohydrolase
nudG (gene name)
Systematic name:
(deoxy)cytidine 5'-triphosphate diphosphohydrolase



The enzyme, characterized from the bacterium Escherichia coli, is specific for the pyrimidine nucleotides CTP and dCTP. It also acts on 5-methyl-dCTP, 5-hydroxy-dCTP and 8-hydroxy-dGTP.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. O'Handley, S. F., Dunn, C. A., Bessman, M. J.
    Orf135 from Escherichia coli Is a Nudix hydrolase specific for CTP, dCTP, and 5-methyl-dCTP.
    J. Biol. Chem. 276 : 5421-5426 (2001). [PMID: 11053429]
  2. Fujikawa, K., Kasai, H.
    The oxidized pyrimidine ribonucleotide, 5-hydroxy-CTP, is hydrolyzed efficiently by the Escherichia coli recombinant Orf135 protein.
    DNA Repair (Amst.) 1 : 571-576 (2002). [PMID: 12509230]
  3. Kamiya, H., Iida, E., Harashima, H.
    Important amino acids in the phosphohydrolase module of Escherichia coli Orf135.
    Biochem. Biophys. Res. Commun. 323 : 1063-1068 (2004). [PMID: 15381107]
  4. Iida, E., Satou, K., Mishima, M., Kojima, C., Harashima, H., Kamiya, H.
    Amino acid residues involved in substrate recognition of the Escherichia coli Orf135 protein.
    Biochemistry 44 : 5683-5689 (2005). [PMID: 15823026]

[EC created 2013]