EC 3.6.1.65 - (d)CTP diphosphatase
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IntEnz Enzyme Nomenclature
EC 3.6.1.65
Names
Accepted name:
(d)CTP diphosphatase
Other
names:
(d)CTP pyrophosphohydrolase
(d)CTP diphosphohydrolase
nudG (gene name)
(d)CTP diphosphohydrolase
nudG (gene name)
Systematic name:
(deoxy)cytidine 5'-triphosphate diphosphohydrolase
Reactions
- (1) CTP + H2O = CMP + diphosphate
- (2) dCTP + H2O = dCMP + diphosphate
Comments:
The enzyme, characterized from the bacterium Escherichia coli, is specific for the pyrimidine nucleotides CTP and dCTP. It also acts on 5-methyl-dCTP, 5-hydroxy-dCTP and 8-hydroxy-dGTP.
Links to other databases
UniProtKB/Swiss-Prot:
NUDG_ECOLI
References
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Orf135 from Escherichia coli Is a Nudix hydrolase specific for CTP, dCTP, and 5-methyl-dCTP.J. Biol. Chem. 276 : 5421-5426 (2001). [PMID: 11053429]
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The oxidized pyrimidine ribonucleotide, 5-hydroxy-CTP, is hydrolyzed efficiently by the Escherichia coli recombinant Orf135 protein.DNA Repair (Amst.) 1 : 571-576 (2002). [PMID: 12509230]
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Important amino acids in the phosphohydrolase module of Escherichia coli Orf135.Biochem. Biophys. Res. Commun. 323 : 1063-1068 (2004). [PMID: 15381107]
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Amino acid residues involved in substrate recognition of the Escherichia coli Orf135 protein.Biochemistry 44 : 5683-5689 (2005). [PMID: 15823026]
[EC 3.6.1.65 created 2013]