EC 3.6.1.54 - UDP-2,3-diacylglucosamine diphosphatase

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IntEnz Enzyme Nomenclature
EC 3.6.1.54

Names

Accepted name:
UDP-2,3-diacylglucosamine diphosphatase
Other names:
LpxH
UDP-2,3-diacylglucosamine hydrolase
UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine diphosphatase
ybbF
UDP-2,3-diacylglucosamine pyrophosphatase
UDP-2,3-bis[(3R)-3-hydroxymyristoyl]-α-D-glucosamine 2,3-bis[(3R)-3-hydroxymyristoyl]-β-D-glucosaminyl 1-phosphate phosphohydrolase [incorrect]
Systematic name:
UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-α-D-glucosamine 2-N,3-O-bis[(3R)-3-hydroxyacyl]-α-D-glucosaminyl 1-phosphate phosphohydrolase

Reactions

Comments:

The enzyme catalyses a step in the biosynthesis of lipid A. Formerly EC 3.6.1.n5.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (162) [show] [UniProt]

References

  1. Babinski, K. J., Ribeiro, A. A., Raetz, C. R.
    The Escherichia coli gene encoding the UDP-2,3-diacylglucosamine pyrophosphatase of lipid A biosynthesis.
    J. Biol. Chem. 277 : 25937-25946 (2002). [PMID: 12000770]
  2. Babinski, K. J., Kanjilal, S. J., Raetz, C. R.
    Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene.
    J. Biol. Chem. 277 : 25947-25956 (2002). [PMID: 12000771]
  3. Okada, C., Wakabayashi, H., Kobayashi, M., Shinoda, A., Tanaka, I., Yao, M.
    Crystal structures of the UDP-diacylglucosamine pyrophosphohydrase LpxH from Pseudomonas aeruginosa.
    Sci Rep 6 : 32822 (2016). [PMID: 27609419]
  4. Cho, J., Lee, C. J., Zhao, J., Young, H. E., Zhou, P.
    Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis.
    Nat Microbiol 1 : 16154 (2016). [PMID: 27780190]
  5. Arenas, J., Pupo, E., de Jonge, E., Perez-Ortega, J., Schaarschmidt, J., van der Ley, P., Tommassen, J.
    Substrate specificity of the pyrophosphohydrolase LpxH determines the asymmetry of Bordetella pertussis lipid A.
    J Biol Chem 294 : 7982-7989 (2019). [PMID: 30926608]

[EC 3.6.1.54 created 2010]