EC 3.6.1.45 - UDP-sugar diphosphatase
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IntEnz Enzyme Nomenclature
EC 3.6.1.45
Names
Accepted name:
UDP-sugar diphosphatase
Other
names:
UDP-sugar hydrolase
UDP-sugar pyrophosphatase
nucleosidediphosphate-sugar diphosphatase
nucleosidediphosphate-sugar pyrophosphatase
UDP-sugar pyrophosphatase
nucleosidediphosphate-sugar diphosphatase
nucleosidediphosphate-sugar pyrophosphatase
Systematic name:
UDP-sugar sugarphosphohydrolase
Reaction
- UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate
Cofactor
Comments:
A divalent cation is required for activity. UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. Thus, this enzyme has a specificity distinct from that of ADP-sugar diphosphatase (EC 3.6.1.21). Some but not all enzymes of this class also appear to have 5'-nucleotidase (see EC 3.1.3.5) activity.
Links to other databases
Protein domains and families:
PROSITE:PDOC00627
Gene Ontology:
GO:0008768
CAS Registry Numbers:
103716-25-2
103716-26-3
57127-20-5
References
-
Isolation, molecular characterization and expression of the ushB gene of Salmonella typhimurium which encodes a membrane bound UDP-sugar hydrolase.Mol. Microbiol. 3 : 177-186 (1989). [PMID: 2548058]
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Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor.J. Biol. Chem. 242 : 1944-1954 (1987).
[EC 3.6.1.45 created 1999]