EC - Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)

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IntEnz Enzyme Nomenclature


Accepted name:
bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
Other names:
Ap4A hydrolase
adenosine tetraphosphate phosphodiesterase
bis(5'-adenosyl) tetraphosphatase
diadenosine 5',5'''-P1,P4-tetraphosphatase
diadenosine polyphosphate hydrolase
diadenosine tetraphosphate hydrolase
diadenosinetetraphosphatase (symmetrical)
dinucleosidetetraphosphate (symmetrical)
symmetrical diadenosine tetraphosphate hydrolase
1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase
Systematic name:
P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase



Also acts on bis(5'-guanosyl) tetraphosphate and bis(5'-adenosyl) pentaphosphate and, more slowly, on some other polyphosphates, forming a nucleoside bisphosphate as one product in all cases [cf. EC bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008803
CAS Registry Number: 85638-48-8
UniProtKB/Swiss-Prot: (203) [show] [UniProt]


  1. Barnes, L.D. and Culver, C.A.
    Isolation and characterization of diadenosine 5',5'''-P1, P4-tetraphosphate pyrophosphohydrolase from Physarum polycephalum.
    Biochemistry 21 : 6123-6128 (1982). [PMID: 6295456]
  2. Guranowski, A., Jakubowski, H. and Holler, E.
    Catabolism of diadenosine 5',5'''-P1, P4-tetraphosphate in procaryotes. Purification and properties of diadenosine 5',5'''-P1,P4-tetraphosphate (symmetrical) pyrophosphohydrolase from Escherichia coli K12.
    J. Biol. Chem. 258 : 14784-14789 (1983). [PMID: 6317672]

[EC created 1986]