EC - Guanosine-5'-triphosphate,3'-diphosphate diphosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
guanosine-5'-triphosphate,3'-diphosphate diphosphatase
Other names:
guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase
guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase
guanosine pentaphosphatase
guanosine pentaphosphate phosphatase
guanosine pentaphosphate phosphohydrolase
guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
pppGpp 5'-phosphohydrolase
Systematic name:
guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase



Also hydrolyses other guanosine 5'-triphosphate derivatives with at least one unsubstituted phosphate group on the 3'-position, but not GTP, ATP or adenosine 5'-triphosphate,3'-diphosphate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008894
CAS Registry Number: 85130-44-5
UniProtKB/Swiss-Prot: (77) [show] [UniProt]


  1. Hara, A. and Sy, J.
    Guanosine 5'-triphosphate, 3'-diphosphate 5'-phosphohydrolase. Purification and substrate specificity.
    J. Biol. Chem. 258 : 1678-1683 (1983). [PMID: 6130093]

[EC created 1986, modified 2010]