EC - FAD diphosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
FAD diphosphatase
Other names:
FAD pyrophosphatase
flavin adenine dinucleotide pyrophosphatase
flavine adenine dinucleotide pyrophosphatase
riboflavin adenine dinucleotide pyrophosphatase
riboflavine adenine dinucleotide pyrophosphatase
Systematic name:
FAD nucleotidohydrolase



The plant enzyme also hydrolyses NAD+ and NADH; the animal enzyme hydrolyses NAD+ and CoA at about half of the rate of hydrolysis of FAD. May be identical with EC nucleotide diphosphatase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047884
CAS Registry Number: 37289-30-8


  1. Ravindranath, S.D. and Appaji Rao, N.
    Nucleotidases in plants. 3. Effect of metabolites on the enzyme hydrolyzing flavine adenine dinucleotide (FAD) from Phaseolus radiatus.
    Arch. Biochem. Biophys. 133 : 54-59 (1969). [PMID: 5810832]
  2. Shin, H.J. and Mego, J.L.
    A rat liver lysosomal membrane flavin-adenine dinucleotide phosphohydrolase: purification and characterization.
    Arch. Biochem. Biophys. 267 : 95-103 (1988). [PMID: 2848456]

[EC created 1972]