EC - Nucleoside-triphosphate phosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
nucleoside-triphosphate phosphatase
Other names:
nucleoside 5-triphosphatase
nucleoside triphosphate phosphohydrolase
nucleoside-5-triphosphate phosphohydrolase
nucleoside triphosphate hydrolase
Systematic name:
unspecific diphosphate phosphohydrolase



The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. Also hydrolyses nucleoside diphosphates, thiamine diphosphate and FAD. The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin [5].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00952
Structural data: CSA , EC2PDB
CAS Registry Number: 9075-51-8
UniProtKB/Swiss-Prot: (313) [show] [UniProt]


  1. Brightwell, R. and Tappel, A.L.
    Lysosomal acid pyrophosphatase and acid phosphatase.
    Arch. Biochem. Biophys. 124 : 333-343 (1968). [PMID: 5661608]
  2. Lewis, M. and Weissman, S.
    Properties of a soluble nucleoside triphosphatase activity in mammalian liver.
    Arch. Biochem. Biophys. 109 : 490-498 (1965). [PMID: 14320490]
  3. Matsushita, S. and Raacke, I.D.
    Purification of nucleoside triphosphatases from pea seedling ribosomes.
    Biochim. Biophys. Acta 166 : 707-710 (1968). [PMID: 4301913]
  4. Tong, C. G., Dauwalder, M., Clawson, G. A., Hatem, C. L., Roux, S. J.
    The major nucleoside triphosphatase in pea (Pisum sativum L.) nuclei and in rat liver nuclei share common epitopes also present in nuclear lamins.
    Plant Physiol. 101 : 1005-1011 (1993). [PMID: 7508630]
  5. Hsieh, H. L., Tong, C. G., Thomas, C., Roux, S. J.
    Light-modulated abundance of an mRNA encoding a calmodulin-regulated, chromatin-associated NTPase in pea.
    Plant Mol. Biol. 30 : 135-147 (1996). [PMID: 8616230]
  6. Klinger, C., Rossbach, M., Howe, R., Kaufmann, M.
    Thermophile-specific proteins: the gene product of aq_1292 from Aquifex aeolicus is an NTPase.
    BMC Biochem. 4 : 12 (2003). [PMID: 14503925]
  7. Placzek, W. J., Almeida, M. S., Wuthrich, K.
    NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase.
    J. Mol. Biol. 367 : 788-801 (2007). [PMID: 17291528]

[EC created 1972]