EC - Inorganic diphosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
inorganic diphosphatase
Other names:
pyrophosphate phosphohydrolase
inorganic pyrophosphatase
Systematic name:
diphosphate phosphohydrolase



Specificity varies with the source and with the activating metal ion. The enzyme from some sources may be identical with EC (alkaline phosphatase) or EC (glucose-6-phosphatase). cf. EC, H+-exporting diphosphatase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00325
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004427
CAS Registry Number: 9024-82-2
UniProtKB/Swiss-Prot: (301) [show] [UniProt]


  1. Bailey, K. and Webb, E.C.
    Purification and properties of yeast pyrophosphatase.
    Biochem. J. 38 : 394-398 (1944). [PMID: 16747821]
  2. Kunitz, M.
    Crystalline inorganic pyrophosphatase isolated from baker's yeast.
    J. Gen. Physiol. 35 : 423-450 (1952). [PMID: 14898026]
  3. Rafter, G.W.
    Pyrophosphate metabolism in liver mitochondria.
    J. Biol. Chem. 235 : 2475-2477 (1960). [PMID: 14435825]

[EC created 1961, modified 2000, modified 2018]