EC - 2-aminomuconate deaminase

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IntEnz Enzyme Nomenclature


Accepted name:
2-aminomuconate deaminase
Other names:
amnD (gene name)
nbaF (gene name)
Systematic name:
2-aminomuconate aminohydrolase



2-aminomuconate is an intermediate in the bacterial biodegradation of nitrobenzene. The enzyme has been isolated from several species, including Pseudomonas pseudocaligenes JS45, Pseudomonas fluorescens KU-7, Pseudomonas sp. AP3 and Burkholderia cenocepacia J2315. The reaction is spontaneous in acid conditions.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050540


  1. He, Z, and Spain, J.C.
    Studies of the catabolic pathway of degradation of nitrobenzene by Pseudomonas pseudoalcaligenes JS45: removal of the amino group from 2-aminomuconic semialdehyde.
    Appl. Environ. Microbiol. 63 : 4839-4843 (1997). [PMID: 9471964]
  2. He, Z. and Spain, J.C.
    A novel 2-aminomuconate deaminase in the nitrobenzene degradation pathway of Pseudomonas pseudoalcaligenes JS45.
    J. Bacteriol. 180 : 2502-2506 (1998). [PMID: 9573204]
  3. Takenaka, S., Murakami, S., Kim, Y. J., Aoki, K.
    Complete nucleotide sequence and functional analysis of the genes for 2-aminophenol metabolism from Pseudomonas sp. AP-3.
    Arch. Microbiol. 174 : 265-272 (2000). [PMID: 11081795]
  4. Muraki, T., Taki, M., Hasegawa, Y., Iwaki, H., Lau, P. C.
    Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomonas fluorescens strain KU-7.
    Appl. Environ. Microbiol. 69 : 1564-1572 (2003). [PMID: 12620844]

[EC created 2000, modified 2012]