EC 3.5.4.8 - Aminoimidazolase

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IntEnz Enzyme Nomenclature
EC 3.5.4.8

Names

Accepted name:
aminoimidazolase
Other names:
4-aminoimidazole hydrolase
4-aminoimidazole deaminase
Systematic name:
4-aminoimidazole aminohydrolase

Reaction

Cofactor

Comments:

Requires Fe2+. This enzyme forms part of the xanthine-degradation pathway in some bacteria. The product of the reaction, imidazol-4-one, can be converted non-enzymically into formiminoglycine. An enzyme has been identified in Clostridium cylindrosporum that can perform this hydrolysis reaction [2,3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047664
CAS Registry Number: 9025-17-6

References

  1. Rabinowitz, J.C. and Pricer, W.E.
    Purine fermentation by Clostridium cylindrosporum. V. Formiminoglycine.
    J. Biol. Chem. 222: 537-554 (1956). [PMID: 13367024]
  2. Freter, K., Rabinowitz, J.C. and Witkop, B.
    Labile Stoffwechselprodukte. V. Zur Biogenese des Formiminoglycins aus 4(5H)-imidazolon.
    Ann. Chem. 607: 174-187 (1957).
  3. Vogels, G.D. and Van der Drift, C.
    Degradation of purines and pyrimidines by microorganisms.
    Bacteriol. Rev. 40: 403-468 (1976). [PMID: 786256]
  4. Vogels, G.D. and Van der Drift, C.
    Erratum report. Degradation of purines and pyrimidines by microorganisms.
    Bacteriol. Rev. 40: 963 (1976).
  5. DeMoll, E. and Auffenberg, T.
    Purine metabolism in Methanococcus vannielii.
    J. Bacteriol. 175: 5754-5761 (1993). [PMID: 8376322]

[EC 3.5.4.8 created 1961]