EC 3 - Hydrolases
EC 3.5 - Acting on carbon-nitrogen bonds, other than peptide bonds
EC 3.5.4 - In cyclic amidines
EC 3.5.4.5 - Cytidine deaminase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.5.4.5
Names
Accepted name:
cytidine deaminase
Other
names:
cytosine nucleoside deaminase
cytidine aminohydrolase
(deoxy)cytidine deaminase
cdd (gene name)
CDA (gene name)
cytidine aminohydrolase
(deoxy)cytidine deaminase
cdd (gene name)
CDA (gene name)
Systematic name:
cytidine/2'-deoxycytidine aminohydrolase
Reactions
- (1) cytidine + H2O = uridine + NH3
- (2) 2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3
Cofactor
Comments:
Contains zinc. Catalyses the deamination of cytidine and 2'-deoxycytidine with similar efficiencies. The enzyme, which is widely distributed among organisms, is involved in salvage of both exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ERGO
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
NIST 74
,
UniPathway
Protein domains and families:
PROSITE:PDOC00702
Gene Ontology:
GO:0004126
CAS Registry Number:
9025-06-3
References
-
The wheat leaf phosphatases. II. Pathway of hydrolysis of some nucleotides at pH 5.5.J. Biol. Chem. 222 : 259-270 (1956). [PMID: 13366999]
-
Enzymatic deamination of cytosine nucleosides.J. Biol. Chem. 184 : 17-28 (1950). [PMID: 15421968]
-
Chromosomal location, cloning and nucleotide sequence of the Bacillus subtilis cdd gene encoding cytidine/deoxycytidine deaminase.Mol. Gen. Genet. 216 : 462-468 (1989). [PMID: 2526291]
-
Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA.Cancer Res. 54 : 5401-5407 (1994). [PMID: 7923172]
-
Cloning, expression, and purification of cytidine deaminase from Arabidopsis thaliana.Protein Expr. Purif. 15 : 8-15 (1999). [PMID: 10024464]
[EC 3.5.4.5 created 1961, (EC 3.5.4.14 created 1972, incorporated 2013), modified 2013]