EC 3.5.4.43 - Hydroxydechloroatrazine ethylaminohydrolase

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IntEnz Enzyme Nomenclature
EC 3.5.4.43

Names

Accepted name:
hydroxydechloroatrazine ethylaminohydrolase
Other names:
atzB (gene name)
2,4-dihydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase
hydroxyatrazine hydrolase
Systematic name:
hydroxyatrazine ethylaminohydrolase

Reaction

Cofactor

Comments:

Contains Zn2+. This bacterial enzyme is involved in degradation of the herbicide atrazine. The enzyme has a broad substrate range, and requires a monohydroxylated S-triazine ring with a minimum of one primary or secondary amine substituent and either a chloride or amine leaving group. It catalyses both deamination and dechlorination reactions.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018763
UniProtKB/Swiss-Prot:

References

  1. Boundy-Mills, K.L., de Souza, M.L., Mandelbaum, R.T., Wackett, L.P. and Sadowsky, M.J.
    The atzB gene of Pseudomonas sp. strain ADP encodes the second enzyme of a novel atrazine degradation pathway.
    Appl. Environ. Microbiol. 63 : 916-923 (1997). [PMID: 9055410]
  2. Seffernick, J. L., Aleem, A., Osborne, J. P., Johnson, G., Sadowsky, M. J., Wackett, L. P.
    Hydroxyatrazine N-ethylaminohydrolase (AtzB): an amidohydrolase superfamily enzyme catalyzing deamination and dechlorination.
    J. Bacteriol. 189 : 6989-6997 (2007). [PMID: 17660279]

[EC 3.5.4.43 created 2000 as EC 3.5.99.3, transferred 2016 to EC 3.5.4.43]