EC 3.5.4.39 - GTP cyclohydrolase IV

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IntEnz Enzyme Nomenclature
EC 3.5.4.39

Names

Accepted name:
GTP cyclohydrolase IV
Other names:
MptA
GTP cyclohydrolase MptA
Systematic name:
GTP 7,8-8,9-dihydrolase (cyclizing, formate-releasing, diphosphate-releasing)

Reaction

Cofactor

Comments:

Requires Fe2+. A zinc protein. The enzyme is involved in methanopterin biosynthesis in methanogenic archaea. cf. GTP cyclohydrolase I (EC 3.5.4.16), GTP cyclohydrolase II (EC 3.5.4.25) and GTP cyclohydrolase IIa (EC 3.5.4.29).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (37) [show] [UniProt]

References

  1. Grochowski, L. L., Xu, H., Leung, K., White, R. H.
    Characterization of an Fe2+-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii.
    Biochemistry 46 : 6658-6667 (2007). [PMID: 17497938]

[EC 3.5.4.39 created 2013]