EC - Double-stranded RNA adenine deaminase

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IntEnz Enzyme Nomenclature


Accepted name:
double-stranded RNA adenine deaminase
Other names:
double-stranded RNA adenosine deaminase
dsRNA adenosine deaminase
double-stranded RNA-specific adenosine deaminase
Systematic name:
double-stranded RNA adenine aminohydrolase



This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (25) [show] [UniProt]


  1. Hough, R. F., Bass, B. L.
    Purification of the Xenopus laevis double-stranded RNA adenosine deaminase.
    J. Biol. Chem. 269 : 9933-9939 (1994). [PMID: 8144588]
  2. O'Connell, M. A., Gerber, A., Keegan, L. P.
    Purification of native and recombinant double-stranded RNA-specific adenosine deaminases.
    Methods 15 : 51-62 (1998). [PMID: 9614652]
  3. Wong, S. K., Sato, S., Lazinski, D. W.
    Substrate recognition by ADAR1 and ADAR2.
    RNA 7 : 846-858 (2001). [PMID: 11421361]
  4. Macbeth, M. R., Schubert, H. L., Vandemark, A. P., Lingam, A. T., Hill, C. P., Bass, B. L.
    Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.
    Science 309 : 1534-1539 (2005). [PMID: 16141067]

[EC created 2013]