EC - N-succinylarginine dihydrolase

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IntEnz Enzyme Nomenclature


Accepted name:
N-succinylarginine dihydrolase
Other names:
N2-succinylarginine dihydrolase
arginine succinylhydrolase
2-N-succinyl-L-arginine iminohydrolase (decarboxylating)
Systematic name:
N2-succinyl-L-arginine iminohydrolase (decarboxylating)



Arginine, N2-acetylarginine and N2-glutamylarginine do not act as substrates [3]. This is the second enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC (arginine N-succinyltransferase), EC (N-succinylarginine dihydrolase), EC (succinylornithine transaminase), EC (succinylglutamate semialdehyde dehydrogenase) and EC (succinylglutamate desuccinylase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0009015
UniProtKB/Swiss-Prot: (138) [show] [UniProt]


  1. Schneider, B.L., Kiupakis, A.K. and Reitzer, L.J.
    Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli.
    J. Bacteriol. 180 : 4278-4286 (1998). [PMID: 9696779]
  2. Tocilj, A., Schrag, J. D., Li, Y., Schneider, B. L., Reitzer, L., Matte, A. and Cygler, M.
    Crystal structure of N-succinylarginine dihydrolase AstB, bound to substrate and product, an enzyme from the arginine catabolic pathway of Escherichia coli.
    J. Biol. Chem. 280 : 15800-15808 (2005). [PMID: 15703173]
  3. Vander Wauven, C. and Stalon, V.
    Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia.
    J. Bacteriol. 164 : 882-886 (1985). [PMID: 2865249]
  4. Cunin, R., Glansdorff, N., Pierard, A. and Stalon, V.
    Biosynthesis and metabolism of arginine in bacteria.
    Microbiol. Rev. 50 : 314-352 (1986). [PMID: 3534538]
  5. Itoh, Y.
    Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa.
    J. Bacteriol. 179 : 7280-7290 (1997). [PMID: 9393691]

[EC created 2006]