EC 3.5.2.18 - Enamidase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 3.5.2.18

Names

Accepted name:
enamidase
Systematic name:
6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase

Reaction

Cofactors

Comments:

Contains iron and Zn2+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 1.1.1.291 (2-hydroxymethylglutarate dehydrogenase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Δ-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043792
UniProtKB/Swiss-Prot:

References

  1. Alhapel, A., Darley, D.J., Wagener, N., Eckel, E., Elsner, N. and Pierik, A.J.
    Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
    Proc. Natl. Acad. Sci. USA 103: 12341-12346 (2006). [PMID: 16894175]

[EC 3.5.2.18 created 2006]