EC - Fatty acid amide hydrolase

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IntEnz Enzyme Nomenclature


Accepted name:
fatty acid amide hydrolase
Other names:
oleamide hydrolase
anandamide amidohydrolase
Systematic name:
fatty acylamide amidohydrolase



Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00494
Structural data: CSA , EC2PDB
Gene Ontology: GO:0103073 , GO:0102077


  1. Boger, D. L., Fecik, R. A., Patterson, J. E., Miyauchi, H., Patricelli, M. P., Cravatt, B. F.
    Fatty acid amide hydrolase substrate specificity.
    Bioorg. Med. Chem. Lett. 10: 2613-2616 (2000). [PMID: 11128635]
  2. Patricelli, M. P., Lashuel, H. A., Giang, D. K., Kelly, J. W., Cravatt, B. F.
    Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization.
    Biochemistry 37: 15177-15187 (1998). [PMID: 9790682]
  3. Patricelli, M. P., Cravatt, B. F.
    Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase.
    Biochemistry 40: 6107-6115 (2001). [PMID: 11352748]

[EC created 2009]