EC 3 - Hydrolases
EC 3.5 - Acting on carbon-nitrogen bonds, other than peptide bonds
EC 3.5.1 - In linear amides
EC 3.5.1.98 - Histone deacetylase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.5.1.98
Names
Accepted name:
histone deacetylase
Other
name:
HDAC
Systematic name:
histone amidohydrolase
Reaction
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58196 [IUBMB]H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)N6-acetyl-L-lysyl-[histone]GENERIC:11338Is ROOT: no
ROOT compound: GENERIC:9844Number of residues: 1=acetateName origin: UniProt - CHECKED (C)Formula: C2H3O2
Charge: -1ChEBI compound status: CHECKED (C)
Comments:
A class of enzymes that remove acetyl groups from N6-acetyl-lysine residues on a histone. The reaction of this enzyme is opposite to that of EC 2.3.1.48, histone acetyltransferase. Histone deacetylases (HDACs) can be organized into three classes, HDAC1, HDAC2 and HDAC3, depending on sequence similarity and domain organization. Histone acetylation plays an important role in regulation of gene expression. In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation [4]. May be identical to EC 3.5.1.17, acyl-lysine deacylase.
Links to other databases
Gene Ontology:
GO:0032041
,
GO:0004407
References
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Chemical studies of histone acetylation. Substrate specificity of a histone deacetylase from calf thymus nuclei.J. Biol. Chem. 249 : 332-334 (1974). [PMID: 4855628]
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Properties of the yeast nuclear histone deacetylase.Biochem. J. 303 : 723-729 (1994). [PMID: 7980438]
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Histone deacetylase enzymes as potential drug targets in cancer and parasitic diseases.J. Biomed. Biotechnol. 2006 : 13474 (2006). [PMID: 16883049]
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Cloning, expression, and biochemical characterization of a new histone deacetylase-like protein from Thermus caldophilus GK24.Biochem. Biophys. Res. Commun. 361 : 55-61 (2007). [PMID: 17632079]
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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.Nature 401 : 188-193 (1999). [PMID: 10490031]
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Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.J. Biol. Chem. 276 : 36734-36741 (2001). [PMID: 11473107]
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Histone deacetylases (HDACs): characterization of the classical HDAC family.Biochem. J. 370 : 737-749 (2003). [PMID: 12429021]
[EC 3.5.1.98 created 2008]