EC 3.5.1.94 - γ-glutamyl-γ-aminobutyrate hydrolase

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IntEnz Enzyme Nomenclature
EC 3.5.1.94

Names

Accepted name:
γ-glutamyl-γ-aminobutyrate hydrolase
Other names:
γ-glutamyl-GABA hydrolase
PuuD
YcjL
4-(γ--glutamylamino)butanoate amidohydrolase
Systematic name:
4-γ-(L-glutamylamino)butanoate amidohydrolase

Reaction

Comments:

Forms part of a novel putrescine-utilizing pathway in Escherichia coli, in which it has been hypothesized that putrescine is first glutamylated to form γ-glutamylputrescine, which is oxidized to 4-(γ-glutamylamino)butanal and then to 4-(γ-glutamylamino)butanoate. The enzyme can also catalyse the reactions of EC 3.5.1.35 (D-glutaminase) and EC 3.5.1.65 (theanine hydrolase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033969
UniProtKB/Swiss-Prot:

References

  1. Kurihara, S., Oda, S., Kato, K., Kim, H. G., Koyanagi, T., Kumagai, H. and Suzuki, H.
    A novel putrescine utilization pathway involves γ-glutamylated intermediates of Escherichia coli K-12.
    J. Biol. Chem. 280: 4602-4608 (2005). [PMID: 15590624]

[EC 3.5.1.94 created 2006, modified 2011]