IntEnz

EC 3.5.1.94 - γ-glutamyl-γ-aminobutyrate hydrolase

IntEnz Enzyme Nomenclature
EC 3.5.1.94

Names

Reaction

• 19737 [IUBMB]
  4-(γ-L-glutamylamino)butanoate

  4-(gamma-L-glutamylamino)butanoate

  Name origin: UniProt - CHECKED (C)

  CHEBI:58800

  Formula: C9H15N2O5
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  4-aminobutanoate

  4-aminobutanoate

  Name origin: UniProt - CHECKED (C)

  CHEBI:59888

  Formula: C4H9NO2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  L-glutamate

  L-glutamate

  Name origin: UniProt - CHECKED (C)

  CHEBI:29985

  Formula: C5H8NO4
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

Comments:

Forms part of a novel putrescine-utilizing pathway in Escherichia coli, in which it has been hypothesized that putrescine is first glutamylated to form γ-glutamylputrescine, which is oxidized to 4-(γ-glutamylamino)butanal and then to 4-(γ-glutamylamino)butanoate. The enzyme can also catalyse the reactions of EC 3.5.1.35 (D-glutaminase) and EC 3.5.1.65 (theanine hydrolase).

Links to other databases

References

1. Kurihara, S., Oda, S., Kato, K., Kim, H. G., Koyanagi, T., Kumagai, H. and Suzuki, H.
   A novel putrescine utilization pathway involves γ-glutamylated intermediates of Escherichia coli K-12.
   J. Biol. Chem. 280: 4602-4608 (2005). [PMID: 15590624]

[EC 3.5.1.94 created 2006, modified 2011]