EC 3 - Hydrolases
EC 3.5 - Acting on carbon-nitrogen bonds, other than peptide bonds
EC 3.5.1 - In linear amides
EC 3.5.1.94 - γ-glutamyl-γ-aminobutyrate hydrolase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.5.1.94
Names
Accepted name:
γ-glutamyl-γ-aminobutyrate hydrolase
Other
names:
γ-glutamyl-GABA hydrolase
PuuD
YcjL
4-(γ--glutamylamino)butanoate amidohydrolase
PuuD
YcjL
4-(γ--glutamylamino)butanoate amidohydrolase
Systematic name:
4-γ-(L-glutamylamino)butanoate amidohydrolase
Reaction
- 4-(gamma-L-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate
Comments:
Forms part of a novel putrescine-utilizing pathway in Escherichia coli, in which it has been hypothesized that putrescine is first glutamylated to form γ-glutamylputrescine, which is oxidized to 4-(γ-glutamylamino)butanal and then to 4-(γ-glutamylamino)butanoate. The enzyme can also catalyse the reactions of EC 3.5.1.35 (D-glutaminase) and EC 3.5.1.65 (theanine hydrolase).
Links to other databases
Gene Ontology:
GO:0033969
UniProtKB/Swiss-Prot:
References
-
A novel putrescine utilization pathway involves γ-glutamylated intermediates of Escherichia coli K-12.J. Biol. Chem. 280 : 4602-4608 (2005). [PMID: 15590624]
[EC 3.5.1.94 created 2006, modified 2011]