EC - Pantetheine hydrolase

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IntEnz Enzyme Nomenclature


Accepted name:
pantetheine hydrolase
Other names:
Systematic name:
(R)-pantetheine amidohydrolase



The enzyme hydrolyses only one of the amide bonds of pantetheine. The substrate analogues phosphopantetheine and CoA are not substrates. The enzyme recycles pantothenate (vitamin B5) and produces cysteamine, a potent anti-oxidant [5].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC50263
Structural data: CSA , EC2PDB
Gene Ontology: GO:0017159
UniProtKB/Swiss-Prot: (19) [show] [UniProt]


  1. Duprè, S. and Cavallini, D.
    Purification and properties of pantetheinase from horse kidney.
    Methods Enzymol. 62 : 262-267 (1979). [PMID: 440106]
  2. Duprè, S., Chiaraluce, R., Nardini, M., Cannella, C., Ricci, G. and Cavallini, D.
    Continuous spectrophotometric assay of pantetheinase activity.
    Anal. Biochem. 142 : 175-181 (1985). [PMID: 6549111]
  3. Maras, B., Barra, D., Duprè, S. and Pitari, G.
    Is pantetheinase the actual identity of mouse and human vanin-1 proteins?
    FEBS Lett. 461 : 149-152 (1999). [PMID: 10567687]
  4. Aurrand-Lions, M., Galland, F., Bazin, H., Zakharyev, V.M., Imhof, B.A. and Naquet, P.
    Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing.
    Immunity 5 : 391-405 (1996). [PMID: 8934567]
  5. Pitari, G., Malergue, F., Martin, F., Philippe, J.M., Massucci, M.T., Chabret, C., Maras, B., Dupre, S., Naquet, P. and Galland, F.
    Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice.
    FEBS Lett. 483 : 149-154 (2000). [PMID: 11042271]
  6. Martin, F., Malergue, F., Pitari, G., Philippe, J.M., Philips, S., Chabret, C., Granjeaud, S., Mattei, M.G., Mungall, A.J., Naquet, P. and Galland, F.
    Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes.
    Immunogenetics 53 : 296-306 (2001). [PMID: 11491533]
  7. Pace, H.C. and Brenner, C.
    The nitrilase superfamily: classification, structure and function.
    Genome Biol. 2 : 0001.1-0001.9 (2001). [PMID: 11380987]

[EC created 2005]