EC 3.5.1.92 - Pantetheine hydrolase

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IntEnz Enzyme Nomenclature
EC 3.5.1.92

Names

Accepted name:
pantetheine hydrolase
Other names:
pantetheinase
vanin
vanin-1
Systematic name:
(R)-pantetheine amidohydrolase

Reaction

Comments:

The enzyme hydrolyses only one of the amide bonds of pantetheine. The substrate analogues phosphopantetheine and CoA are not substrates. The enzyme recycles pantothenate (vitamin B5) and produces cysteamine, a potent anti-oxidant [5].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC50263
Structural data: CSA , EC2PDB
Gene Ontology: GO:0017159
UniProtKB/Swiss-Prot:

References

  1. Duprè, S. and Cavallini, D.
    Purification and properties of pantetheinase from horse kidney.
    Methods Enzymol. 62: 262-267 (1979). [PMID: 440106]
  2. Duprè, S., Chiaraluce, R., Nardini, M., Cannella, C., Ricci, G. and Cavallini, D.
    Continuous spectrophotometric assay of pantetheinase activity.
    Anal. Biochem. 142: 175-181 (1985). [PMID: 6549111]
  3. Maras, B., Barra, D., Duprè, S. and Pitari, G.
    Is pantetheinase the actual identity of mouse and human vanin-1 proteins?
    FEBS Lett. 461: 149-152 (1999). [PMID: 10567687]
  4. Aurrand-Lions, M., Galland, F., Bazin, H., Zakharyev, V.M., Imhof, B.A. and Naquet, P.
    Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing.
    Immunity 5: 391-405 (1996). [PMID: 8934567]
  5. Pitari, G., Malergue, F., Martin, F., Philippe, J.M., Massucci, M.T., Chabret, C., Maras, B., Dupre, S., Naquet, P. and Galland, F.
    Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice.
    FEBS Lett. 483: 149-154 (2000). [PMID: 11042271]
  6. Martin, F., Malergue, F., Pitari, G., Philippe, J.M., Philips, S., Chabret, C., Granjeaud, S., Mattei, M.G., Mungall, A.J., Naquet, P. and Galland, F.
    Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes.
    Immunogenetics 53: 296-306 (2001). [PMID: 11491533]
  7. Pace, H.C. and Brenner, C.
    The nitrilase superfamily: classification, structure and function.
    Genome Biol. 2: 0001.1-0001.9 (2001). [PMID: 11380987]

[EC 3.5.1.92 created 2005]