EC - Glutathionylspermidine amidase

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IntEnz Enzyme Nomenclature


Accepted name:
glutathionylspermidine amidase
Other names:
glutathionylspermidine amidohydrolase (spermidine-forming)
GSP amidase
Systematic name:
γ-L-glutamyl-L-cysteinyl-glycine:spermidine amidase



Spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule. The enzyme from Escherichia coli is bifunctional and also catalyses the glutathionylspermidine synthase (EC reaction, resulting in a net hydrolysis of ATP.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008884
CAS Registry Number: 171040-71-4


  1. Bollinger, J.M., Kwon, D.S., Huisman, G.W., Kolter, R., Walsh, C.T.
    Glutathionylspermidine metabolism in E. coli. Purification, cloning, overproduction and characterization of a bifunctional glutathionylspermidine synthetase/amidase.
    J. Biol. Chem. 270 : 14031-14041 (1995). [PMID: 7775463]

[EC created 1999]