EC 3.5.1.46 - 6-aminohexanoate-oligomer exohydrolase

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IntEnz Enzyme Nomenclature
EC 3.5.1.46

Names

Accepted name:
6-aminohexanoate-oligomer exohydrolase
Other names:
6-aminohexanoate-dimer hydrolase
nylB (gene name)
6-aminohexanoic acid oligomer hydrolase [ambiguous]
N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase
nylon-6 hydrolase [ambiguous]
Systematic name:
N-(6-aminohexanoyl)-6-aminohexanoate exoamidohydrolase

Reactions

Comments:

The enzyme is involved in degradation of nylon-6 oligomers. It degrades linear oligomers of 6-aminohexanoate with a degree of polymerization of 2-20 by exo-type cleavage, removing residues sequentially from the N-terminus. Activity decreases with the increase of the polymerization number of the oligomer. cf. EC 3.5.1.117, 6-aminohexanoate-oligomer endohydrolase and EC 3.5.2.12, 6-aminohexanoate-cyclic-dimer hydrolase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0019875
CAS Registry Number: 75216-15-8
UniProtKB/Swiss-Prot:

References

  1. Kinoshita, S., Terada, T., Taniguchi, T., Takeney, Y., Masuda, S., Matsunaga, N. and Okada, H.
    Purification and characterization of 6-aminohexanoic-acid-oligomer hydrolase of Flavobacterium sp. Ki72.
    Eur. J. Biochem. 116: 547-551 (1981). [PMID: 7262074]

[EC 3.5.1.46 created 1983, modified 2014]