EC - N-methyl-2-oxoglutaramate hydrolase

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IntEnz Enzyme Nomenclature


Accepted name:
N-methyl-2-oxoglutaramate hydrolase
Other name:
5-hydroxy-N-methylpyroglutamate synthase
Systematic name:
N-methyl-2-oxoglutaramate methylamidohydrolase



In the reverse reaction, the product cyclizes non-enzymically to 2-hydroxy-N-methyl-5-oxoproline.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050130
CAS Registry Number: 9073-53-4


  1. Hersh, L.B.
    5-Hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action.
    J. Biol. Chem. 245: 3526-3535 (1970). [PMID: 5470822]
  2. Hersh, L.B., Tsai, L. and Stadtman, E.R.
    The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid.
    J. Biol. Chem. 244: 4677-4683 (1969). [PMID: 5808511]

[EC created 1972]