EC 3.5.1.123 - γ-glutamylanilide hydrolase

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IntEnz Enzyme Nomenclature
EC 3.5.1.123

Names

Accepted name:
γ-glutamylanilide hydrolase
Other name:
atdA2 (gene name)
Systematic name:
N5-phenyl-L-glutamine amidohydrolase

Reaction

Comments:

The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the opposite reaction from that cayalysed by EC 6.3.1.18, γ-glutamylanilide synthase, which is part of an aniline degradation pathway. Its purpose is likely to maintain a low concentration of N5-phenyl-L-glutamine, which is potentially toxic.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Takeo, M., Ohara, A., Sakae, S., Okamoto, Y., Kitamura, C., Kato, D., Negoro, S.
    Function of a glutamine synthetase-like protein in bacterial aniline oxidation via gamma-glutamylanilide.
    J. Bacteriol. 195: 4406-4414 (2013). [PMID: 23893114]

[EC 3.5.1.123 created 2016]