EC 3.5.1.115 - Mycothiol S-conjugate amidase

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IntEnz Enzyme Nomenclature
EC 3.5.1.115

Names

Accepted name:
mycothiol S-conjugate amidase
Other name:
MCA
Systematic name:
mycothiol S-conjugate 1D-myo-inositol 2-amino-2-deoxy-α-D-glucopyranosyl-hydrolase

Reaction

Comments:

The enzyme that is found in actinomycetes is involved in the detoxification of oxidizing agents and electrophilic antibiotics. The enzyme has low activity with 1-O-(2-acetamido-2-deoxy-α-D-glucopyranosyl)-1D-myo-inositol as substrate (cf. EC 3.5.1.103, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase) [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Newton, G. L., Av-Gay, Y., Fahey, R. C.
    A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase.
    Biochemistry 39 : 10739-10746 (2000). [PMID: 10978158]
  2. Steffek, M., Newton, G. L., Av-Gay, Y., Fahey, R. C.
    Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase.
    Biochemistry 42 : 12067-12076 (2003). [PMID: 14556638]

[EC 3.5.1.115 created 2013]