EC 3.5.1.112 - 2'-N-acetylparomamine deacetylase

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IntEnz Enzyme Nomenclature
EC 3.5.1.112

Names

Accepted name:
2'-N-acetylparomamine deacetylase
Other names:
btrD (gene name)
neoL (gene name)
kanN (gene name)
Systematic name:
2'-N-acetylparomamine hydrolase (acetate-forming)

Reaction

Comments:

Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. The enzyme from the bacterium Streptomyces fradiae can also accept 2'''-acetyl-6'''-hydroxyneomycin C as substrate, cf. EC 3.5.1.113, 2'''-acetyl-6'''-hydroxyneomycin C deacetylase [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Truman, A. W., Huang, F., Llewellyn, N. M., Spencer, J. B.
    Characterization of the enzyme BtrD from Bacillus circulans and revision of its functional assignment in the biosynthesis of butirosin.
    Angew. Chem. Int. Ed. Engl. 46 : 1462-1464 (2007). [PMID: 17226887]
  2. Yokoyama, K., Yamamoto, Y., Kudo, F., Eguchi, T.
    Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis.
    Chembiochem 9 : 865-869 (2008). [PMID: 18311744]

[EC 3.5.1.112 created 2012]