IntEnz - EC 3.5.1.11

EC 3 - Hydrolases

EC 3.5 - Acting on carbon-nitrogen bonds, other than peptide bonds

EC 3.5.1 - In linear amides

EC 3.5.1.11 - Penicillin amidase

IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 3.5.1.11

Names

Accepted name:

penicillin amidase

Other names:

α-acylamino-β-lactam acylhydrolase
ampicillin acylase
benzylpenicillin acylase
novozym 217
penicillin acylase
semacylase

Systematic name:

penicillin amidohydrolase

Reaction

18693 [IUBMB]

H₂O

H2O

Name origin: UniProt - CHECKED (C)

CHEBI:15377

Formula: H2O
Charge: 0

ChEBI compound status: CHECKED (C)

+

penicillin

penicillin

Name origin: UniProt - CHECKED (C)

CHEBI:51356

Formula: C9H10N2O4SR
Charge: -1

ChEBI compound status: CHECKED (C)

=

6-aminopenicillanate

6-aminopenicillanate

Name origin: UniProt - CHECKED (C)

CHEBI:57869

Formula: C8H12N2O3S
Charge: 0

ChEBI compound status: CHECKED (C)

+

a carboxylate

a carboxylate

Name origin: UniProt - CHECKED (C)

CHEBI:29067

Formula: CO2R
Charge: -1

ChEBI compound status: CHECKED (C)

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0008953

CAS Registry Number: 9014-06-6

UniProtKB/Swiss-Prot:

PAC2_PSES3

PAC_ARTVI

PAC_BACME

PAC_ECOLX

PAC_KLUCR

PAC_LYSSH

References

Sakaguchi, K. and Murao, S.

A preliminary report on a new enzyme, "penicillin-amidase".

J. Agric. Chem. Soc. Jpn. 23: 411 (1950).

[EC 3.5.1.11 created 1961]