EC 18.104.22.168 - ADAMTS13 endopeptidase
IntEnz Enzyme Nomenclature
von Willebrand factor cleaving protease
- The enzyme cleaves the von Willebrand factor at bond Tyr842┼Met843 within the A2 domain
In peptidase family M12.
Belongs to peptidase family M12.
Links to other databases
Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family.Blood 98: 1662-1666 (2001). [PMID: 11535495]
ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions.Blood 100: 4033-4039 (2002). [PMID: 12393397]
[EC 22.214.171.124 created 2009]