EC 3.4.24.87 - ADAMTS13 endopeptidase

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IntEnz Enzyme Nomenclature
EC 3.4.24.87

Names

Accepted name:
ADAMTS13 endopeptidase
Other names:
ADAMTS VWF cleaving metalloprotease
ADAMTS-13
ADAMTS13
vWF-cleaving protease
VWF-CP
vWF-degrading protease
Upshaw factor
von Willebrand factor cleaving protease
ADAMTS13 peptidase
Systematic name:
-

Reaction

Comments:

In peptidase family M12.

Belongs to peptidase family M12.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Fujikawa, K., Suzuki, H., McMullen, B., Chung, D.
    Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family.
    Blood 98: 1662-1666 (2001). [PMID: 11535495]
  2. Dong, J. F., Moake, J. L., Nolasco, L., Bernardo, A., Arceneaux, W., Shrimpton, C. N., Schade, A. J., McIntire, L. V., Fujikawa, K., Lopez, J. A.
    ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions.
    Blood 100: 4033-4039 (2002). [PMID: 12393397]

[EC 3.4.24.87 created 2009]