EC 126.96.36.199 - Anthrax lethal factor endopeptidase
IntEnz Enzyme Nomenclature
- Preferred amino acids around the cleavage site can be denoted BBBBxHx┼H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases.
From the bacterium Bacilus anthracis that causes anthrax. One of three proteins that are collectively termed anthrax toxin. Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases. In peptidase family M34.
Links to other databases
Crystal structure of the anthrax lethal factor.Nature 414: 229-233 (2001). [PMID: 11700563]
[EC 188.8.131.52 created 2003]