EC 3.4.24.83 - Anthrax lethal factor endopeptidase

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IntEnz Enzyme Nomenclature
EC 3.4.24.83

Names

Accepted name:
anthrax lethal factor endopeptidase
Other name:
lethal toxin
Systematic name:
-

Reaction

Cofactor

Comments:

From the bacterium Bacilus anthracis that causes anthrax. One of three proteins that are collectively termed anthrax toxin. Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases. In peptidase family M34.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Pannifer, A.D., Wong, T.Y., Schwarzenbacher, R., Renatus, M., Petosa, C., Bienkowska, J., Lacy, D.B., Collier, R.J., Park, S., Leppla, S.H., Hanna, P. and Liddington, R.C.
    Crystal structure of the anthrax lethal factor.
    Nature 414: 229-233 (2001). [PMID: 11700563]

[EC 3.4.24.83 created 2003]