EC - Lysostaphin

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IntEnz Enzyme Nomenclature


Accepted name:
Other name:
glycyl-glycine endopeptidase
Systematic name:




A zinc-dependent, 25-kDa endopeptidase from Staphylococcus simulans. Lyses cells of S. aureus, in particular, by its action on the cross-bridges of the cell wall. Type example of peptidase family M23.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 9011-93-2
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Recsei, P.A., Gruss, A.D. and Novick, R.P.
    Cloning, sequence, and expression of the lysostaphin gene from Staphylococcus simulans.
    Proc. Natl. Acad. Sci. USA 84: 1127-1131 (1987).
  2. Baba, T. and Schneewind, O.
    Target cell specificity of a bacteriocin molecule: A C-terminal signal directs lysostaphin to the cell wall of Staphylococcus aureus.
    EMBO J. 15: 4789-4797 (1996).
  3. Thumm, G. and Götz, F.
    Studies on prolysostaphin processing and characterization of the lysostaphin immunity factor (Lif) of Staphylococcus simulans biovar staphylolyticus.
    Mol. Microbiol. 23: 1251-1265 (1997). [PMID: 9106216]

[EC created 1997]