EC - Endothelin-converting enzyme 1

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
endothelin-converting enzyme 1
Other names:
endothelin-converting enzyme
Systematic name:




A phosphoramidon-sensitive metalloendopeptidase in peptidase family M13 (neprilysin family). An integral membrane protein predominantly of endothelial cells, which generates the potent vasoconstrictor endothelin 1 from its inactive precursor.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004222
CAS Registry Number: 138238-81-0
UniProtKB/Swiss-Prot: (26) [show] [UniProt]


  1. Takahashi, M., Matsushita, Y., Iijima, Y. and Tanzawa, K.
    Purification and characterization of endothelin-converting enzyme from rat lung.
    J. Biol. Chem. 268 : 21394-21398 (1993). [PMID: 8407980]
  2. Shimada, K., Takahashi, M. and Tanzawa, K.
    Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells.
    J. Biol. Chem. 269 : 18275-18278 (1994). [PMID: 8034569]
  3. Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., DeWit, D. and Yanagisawa, M.
    ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1.
    Cell 78 : 473-485 (1994). [PMID: 8062389]

[EC created 1996]