EC 3.4.24.71 - Endothelin-converting enzyme 1

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IntEnz Enzyme Nomenclature
EC 3.4.24.71

Names

Accepted name:
endothelin-converting enzyme 1
Other names:
ECE-1
endothelin-converting enzyme
Systematic name:
-

Reaction

Cofactor

Comments:

A phosphoramidon-sensitive metalloendopeptidase in peptidase family M13 (neprilysin family). An integral membrane protein predominantly of endothelial cells, which generates the potent vasoconstrictor endothelin 1 from its inactive precursor.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016512
CAS Registry Number: 138238-81-0
UniProtKB/Swiss-Prot: (11) [show] [UniProt]

References

  1. Takahashi, M., Matsushita, Y., Iijima, Y. and Tanzawa, K.
    Purification and characterization of endothelin-converting enzyme from rat lung.
    J. Biol. Chem. 268: 21394-21398 (1993). [PMID: 8407980]
  2. Shimada, K., Takahashi, M. and Tanzawa, K.
    Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells.
    J. Biol. Chem. 269: 18275-18278 (1994). [PMID: 8034569]
  3. Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., DeWit, D. and Yanagisawa, M.
    ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1.
    Cell 78: 473-485 (1994). [PMID: 8062389]

[EC 3.4.24.71 created 1996]