EC - Choriolysin H

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
choriolysin H
Other names:
high choriolytic enzyme (HCE)
teleost hatching enzyme (component)
teleost hatching enzyme
high choriolytic enzyme
Systematic name:




Known from the teleost fish Oryzias latipes (medaka). Efficient dissolution of the egg membrane requires concerted action with choriolysin L. A 25.5 kDa peptidase in family M12 (astacin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
CAS Registry Number: 177529-16-7


  1. Yamagami, K.
    Isolation of a choriolytic enzyme (hatching enzyme) of the teleost, Oryzias latipes.
    Dev. Biol. 29: 343-348 (1972).
  2. Yasumasu, S., Iuchi, I. and Yamagami, K.
    Purification and partial characterization of high choriolytic enzyme (HCE), a component of the hatching enzyme of the teleost, Oryzias latipes.
    J. Biochem. (Tokyo) 105: 204-211 (1989). [PMID: 2656664]
  3. Yasumasu, S., Katow, S., Umino, Y., Iuchi, I. and Yamagami, K.
    A unique proteolytic action of HCE, a constituent protease of a fish hatching enzyme: tight binding to its natural substrate, egg envelope.
    Biochem. Biophys. Res. Commun. 162: 58-63 (1989). [PMID: 2751672]
  4. Yasumasu, S., Yamada, K., Akasaka, K., Mitsunaga, K., Iuchi, I., Shimada, H. and Yamagami, K.
    Isolation of cDNAs for LCE and HCE, two constituent proteases of the hatching enzyme of Oryzias latipes, and concurrent expression of their mRNAs during development.
    Dev. Biol. 153: 250-258 (1992). [PMID: 1397682]
  5. Lee, K.S., Yasumasu, S., Nomura, K. and Iuchi, I.
    HCE, a constituent of the hatching enzymes of Oryzias latipes embryos, releases unique proline-rich polypeptides from its natural substrate, the hardened chorion.
    FEBS Lett. 339: 281-284 (1993). [PMID: 8112467]

[EC created 1995]