EC - Meprin B

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IntEnz Enzyme Nomenclature


Accepted name:
meprin B
Other name:
Systematic name:




A brush border membrane-bound metalloendopeptidase known from the intestine of all mouse strains that have been tested, and the kidney of certain inbred strains. A tetramer of meprin b subunits (in contrast to meprin A, which contains both a and b subunits). Occurs in the kidney as a proenzyme that can be activated by trypsin. Meprin B is inhibited by both EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. In peptidase family M12 (astacin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
CAS Registry Number: 150679-52-0


  1. Kounnas, M.Z., Wolz, R.L., Gorbea, C.M. and Bond, J.S.
    Meprin-A and -B. Cell surface endopeptidases of the mouse kidney.
    J. Biol. Chem. 266: 17350-17357 (1991). [PMID: 1894622]
  2. Gorbea, C.M., Marchand, P., Jiang, W., Copeland, N.G., Gilbert, D.J., Jenkins, N.A. and Bond, J.S.
    Cloning, expression, and chromosomal localization of the mouse meprin β subunit.
    J. Biol. Chem. 268: 21035-21043 (1993). [PMID: 8407940]
  3. Johnson, G.D. and Hersh, L.B.
    Expression of meprin subunit precursors. Membrane anchoring through the β subunit and mechanism of zymogen activation.
    J. Biol. Chem. 269: 7682-7688 (1994). [PMID: 14171803]
  4. Wolz, R.L. and Bond, J.S.
    Meprins A and B.
    Methods Enzymol. 248: 325-345 (1995). [PMID: 7674930]

[EC created 1995]