EC - Nardilysin

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
N-arginine dibasic convertase
Systematic name:




Enzyme of 133 kDa from rat brain and testis. A homologue of pitrilysin containing the His-Phe-Leu-Glu-His zinc-binding sequence, and a highly acidic stretch of 71 residues. Unusually for a metalloendopeptidase, inhibited by bestatin, amastatin and N-ethylmaleimide. In peptidase family M16 (pitrilysin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00130
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004222
CAS Registry Number: 157906-54-2


  1. Gomez, S., Gluschankof, P., Morel, A. and Cohen, P.
    The somatostatin-28 convertase of rat brain cortex is associated with secretory granule membranes.
    J. Biol. Chem. 260 : 10541-10545 (1985). [PMID: 3897221]
  2. Gluschankof, P., Gomez, S., Morel, A. and Cohen, P.
    Enzymes that process somatostatin precursors. A novel endoprotease that cleaves before the arginine-lysine doublet is involved in somatostatin-28 convertase activity of rat brain cortex.
    J. Biol. Chem. 262 : 9615-9620 (1987). [PMID: 2885328]
  3. Chesneau, V., Pierotti, A.R., Barré, N., Créminon, C., Tougard, C. and Cohen, P.
    Isolation and characterization of a dibasic selective metalloendopeptidase from rat testes that cleaves at the amino terminus of arginine residues.
    J. Biol. Chem. 269 : 2056-2061 (1994). [PMID: 8294457]
  4. Pierotti, A.R., Prat, A., Chesneau, V., Gaudoux, F., Leseney, A.-M., Foulon, T. and Cohen, P.
    N-Arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes.
    Proc. Natl. Acad. Sci. USA 91 : 6078-6082 (1994). [PMID: 8016118]

[EC created 1995]